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1 the authors proposed that the health benefits of caloric restriction result from a passive reduction in the production of damaging oxygen free radicals. preclinical studies consistently show the robust disease- modifying efficacy of intermittent fasting in animal models on a wide range of chronic disorders, including obesity, diabetes,. intermittent and periodic fasting ( if and pf, respectively) are emerging as safe strategies to affect longevity and healthspan by acting on cellular aging and disease risk factors, while causing no or minor side effects. 1, 2 only in the most recent 200 years have humans been.
in the first paragraph of the intermittent fasting and metabolic switching section ( page 2542), the fifth sentence should have read, “ in the fed effects of intermittent fasting on health aging and disease pdf state, blood levels of ketone bodies are low,. 1056/ nejmra1905136 aging / physiology* diabetes mellitus / diet therapy fasting / physiology* hypertension / diet pdf therapy metabolism / physiology* obesity / diet therapy stress, physiological. effects of intermittent fasting on pdf health, aging, and disease 20; :. 1056/ nejmra1905136. reducing food availability over a lifetime ( caloric restriction) has remark- able effects on aging and the life span in animals.
not only does this method restrict total caloric intake, it also promotes metabolic homeostasis by supporting circadian feeding rhythms. intermittent fasting ( if), or time- restricted feeding, is an emerging dietary intervention that restricts intake of food and energy for a given period.
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